Can anyone offer any advice or share any experience with running DW as a city-focused rather than dungeon/wilderness…

Can anyone offer any advice or share any experience with running DW as a city-focused rather than dungeon/wilderness…

Can anyone offer any advice or share any experience with running DW as a city-focused rather than dungeon/wilderness focused game?  Skulduggery, heists, cons, dirty politics, mysteries and investigation, conflicted loyalties, etc. 

I ask, because I was struck by the notion of converting Wrekkengutt, the dirty little setting I knocked together for the D&D5e playtest.  The campaign is called The Slaughter Season (as Wrekkengutt is like fantasy Chicago during the absolute worst of the meatpacking days).  There are monsters and sewers and occasional invasions, but the focus is mostly on dealing with (near)human enemies, and not always (or often) by spitting them onto spears.  Things do go gloriously and grotesquely wrong quite regularly, of course.  The current plot-line involves mind control delivered by sausages, and troll cancer.